Phenoxy compounds

Medchemexpress LLC 10-methyl-9-(phenoxycarbonyl) acridinium trifluoromethanesulfonate | 161006-14-0 | MFCD01320487 | 99.4% | 463.43 | C22H16F3NO5S | 5 MG

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10-Methyl-9-(phenoxycarbonyl) acridinium trifluoromethanesulfonate is an acridinium-based chemiluminescent reagent used in chemiluminescent assays for sensitive detection of enzymes, antigens, antibodies, and hormones. It converts to a fluorescent acridone upon oxidation and is supplied in small quantities for research and assay development.

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Medchemexpress LLC Prexasertib dimesylate | 1234015-58-7 | MFCD32693943 | 98.9% | 557.60 | C20H27N7O8S2 | 10 MG

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Prexasertib dimesylate is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor supplied as a solid research compound. It causes double-stranded DNA breakage and replication catastrophe that lead to apoptosis, and is offered in multiple solid pack sizes and solution formats for laboratory use. Not for human or clinical use.

• Selective ATP-competitive CHK1 inhibitor.
• Induces DNA double-strand breaks and replication catastrophe.
• High purity: 98.9%.
• Available as solid and as 10 mM solution in DMSO.
• Solubility data provided for in vitro and in vivo protocols.
• Recommended storage: 4°C (solid) and -80°C for stock solutions.

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Medchemexpress LLC Tucatinib hemiethanolate | 1429755-56-5 | 100.0% | 503.57 g·mol⁻¹ | C26H24N8O2 · 1/2 C2H6O | 10 MG

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Tucatinib hemiethanolate is a research-grade small molecule that potently and selectively inhibits HER2 (reported IC50 8 nM). It is supplied as the hemiethanolate salt for analytical and research applications and is not for human therapeutic use.

• Potent HER2 inhibition (IC50 8 nM).
• Selective activity for HER2, supporting targeted research applications.
• High purity suitable for analytical and in vitro studies.
• Available in small research-scale quantities, such as 10 mg.
• Provided with batch-specific certificate of analysis for traceability.

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Medchemexpress LLC L-371,257 | 162042-44-6 | 99.3% | 507.58 | 50 MG

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L-371,257 is an orally bioavailable, non-blood-brain barrier penetrant, selective, and competitive antagonist of the oxytocin receptor. It exhibits high affinity for both the oxytocin receptor (Ki=19 nM) and the vasopressin V1a receptor (Ki=3.7 nM). This compound has been shown to stimulate weight gain in rats when administered systemically at doses of 0.5 and 1.0 mg/kg via intraperitoneal injection.

• Orally bioavailable.
• Does not penetrate the blood-brain barrier.
• Selective and competitive antagonist of the oxytocin receptor.
• High affinity at both the oxytocin receptor (Ki=19 nM) and vasopressin V1a receptor (Ki=3.7 nM).
• Stimulates weight gain in rats.

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Medchemexpress LLC 3-(4-methoxyphenyl)-5-[(5-nitro-2-thienyl)methylene]-2-thioxo-4-thiazolidinone | 346640-08-2 | 98.0% | 378.45 | C15H10N2O4S3 | 25 MG

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CCF642 is a small-molecule protein disulfide isomerase (PDI) inhibitor reported to have an IC50 of 2.9 μM and to induce endoplasmic reticulum stress and apoptosis in multiple myeloma cells. The compound is supplied for research use with documented solubility and storage guidance for experimental workflows.

• Potent PDI inhibition with reported IC50 of 2.9 μM.
• Induces ER stress and apoptosis in multiple myeloma models.
• High solubility in DMSO for in vitro stock preparation.
• Stable as a powder under recommended cold storage conditions.
• Documented in vitro and in vivo formulation guidance for experimental use.

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Medchemexpress LLC PXS-5153A monohydrochloride | 2125956-82-1 | 99.59% | 438.95 | 100 MG

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PXS-5153A monohydrochloride is a potent, selective, orally active, and fast-acting lysyl oxidase like 2/3 enzymatic (LOXL2/LOXL3) inhibitor. It has an IC50 of <40 nM for LOXL2 across all mammalian species and an IC50 of 63 nM for human LOXL3. This compound can reduce crosslinks and ameliorate fibrosis.

• Potent, selective, orally active, and fast-acting LOXL2/LOXL3 inhibitor.
• IC50 of <40 nM for LOXL2 across all mammalian species.
• IC50 of 63 nM for human LOXL3.
• >40-fold selective for LOXL2 over LOX and LOXL1.
• >700-fold selective over other related amine oxidases.
• Fast-acting, with enzymatic activity almost entirely blocked within 15 minutes.
• Reduces crosslinks and ameliorates fibrosis.

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